![]() ![]() Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Interceptor is the go-to heartworm preventive for many Collie parents. Additionally, it can also be given to cats and even pregnant or nursing animals. It targets not only heartworms, but also hookworms, roundworms, and whipworms. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, “treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution.” It really boils down to weighing the benefits of medications against the risks from internal parasites. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. If an MDR1-affected dog were to be treated for mange, that would involve higher dosages and could cause adverse reactions. However, not all ML’s are created equal, and some are safer than others. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. You should still keep an eye on your pet when introducing new organic products.īear with me for a little pharmaceutical science, which I promise is important and will make sense in the end! It’s simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names.Īll the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. But remember, dogs can also be sensitive to essential oils – just like my friend who is allergic to lavender – so “natural” doesn’t automatically mean “best” for your dog either. ![]() This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. In regard to natural products, I’ve used some organic topicals, which I’ll list later, that are somewhat effective as repellents but unfortunately I do not know of any natural pest control products that actually work as well as chemical-based ones. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated “safe- ish.” Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.) If you’re hoping for a quick, easy skim and just want to know which pest protections are considered safe, I’ll list those first under each heading, followed by the “use with caution” category, and finally the “not safe” options.įor those of you who want proof or a more in-depth explanation of why I’ve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. ![]() I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything I’ve researched. I’ll list all the options I looked into (including several I’ve personally tried), along with whether they’re considered safe to use, use with caution, or a complete no-no. (Basically, I did the boring work to bring you the helpful information.) So here’s the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. ![]()
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